Ontology highlight
ABSTRACT:
SUBMITTER: Yumol J
PROVIDER: S-EPMC7642645 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yumol Jacklyn J Gabrielli Brian B Tayyar Yaman Y McMillan Nigel Aj NA Idris Adi A
American journal of cancer research 20201001 10
Human papillomavirus (HPV) is the main causative agent in cervical cancers. Recurrent cervical cancer is refractory to currently available treatments. Clearly there is an urgent unmet need to investigate new therapeutic strategies for both the newly diagnosed and recurrent patient populations. We have previously shown that the presence of HPV oncogenes sensitizes cells to inhibition of aurora kinases (AURKs), which induces mitotic delay eventually leading to apoptotic cell death. In this study, ...[more]