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Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.

ABSTRACT: EuII -containing complexes were studied with respect to properties relevant to their use as contrast agents for magnetic resonance imaging. The influences of molecular parameters and field strength on relaxivity were studied for a series of EuII -containing cryptates and their adducts with ?-cyclodextrins, poly-?-cyclodextrins, and human serum albumin. Solid- and solution-phase characterization of EuII -containing complexes is presented that demonstrates the presence of inner-sphere molecules of water. Additionally, relaxivity, water-exchange rate, rotational correlation time, and electronic relaxation times were determined using variable-temperature 17 O?NMR, nuclear magnetic relaxation dispersion, and electron paramagnetic resonance spectroscopic techniques. These results are expected to be instrumental in the design of future EuII -based contrast agents.

SUBMITTER: Lenora CU

PROVIDER: S-EPMC5668193 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.

Lenora Chamika U CU Carniato Fabio F Shen Yimin Y Latif Zahid Z Haacke E Mark EM Martin Philip D PD Botta Mauro M Allen Matthew J MJ

Chemistry (Weinheim an der Bergstrasse, Germany) 20170822 61

EuII -containing complexes were studied with respect to properties relevant to their use as contrast agents for magnetic resonance imaging. The influences of molecular parameters and field strength on relaxivity were studied for a series of EuII -containing cryptates and their adducts with β-cyclodextrins, poly-β-cyclodextrins, and human serum albumin. Solid- and solution-phase characterization of EuII -containing complexes is presented that demonstrates the pres ...[more]

PMID: 28707809

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