Modulation of telomere protection by the PI3K/AKT pathway.
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ABSTRACT:
SUBMITTER: Mendez-Pertuz M
PROVIDER: S-EPMC5668434 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Modulation of telomere protection by the PI3K/AKT pathway.
Méndez-Pertuz Marinela M Martínez Paula P Blanco-Aparicio Carmen C Gómez-Casero Elena E Belen García Ana A Martínez-Torrecuadrada Jorge J Palafox Marta M Cortés Javier J Serra Violeta V Pastor Joaquin J Blasco Maria A MA
Nature communications 20171102 1
Telomeres and the insulin/PI3K pathway are considered hallmarks of aging and cancer. Here, we describe a role for PI3K/AKT in the regulation of TRF1, an essential component of the shelterin complex. PI3K and AKT chemical inhibitors reduce TRF1 telomeric foci and lead to increased telomeric DNA damage and fragility. We identify the PI3Kα isoform as responsible for this TRF1 inhibition. TRF1 is phosphorylated at different residues by AKT and these modifications regulate TRF1 protein stability and ...[more]
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