Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Dominguez JR
PROVIDER: S-EPMC5669209 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Alvarez-Dominguez Juan R JR Lodish Harvey F HF
Blood 20170919 18
Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components of gene programs controlling cell differentiation and function. Central to their functions is an ability to act as scaffolds or as decoys that recruit or sequester effector proteins from their DNA, RNA, or protein targets. lncRNA-modulated effectors include regulators of transcription, chromatin organization, RNA processing, and translation, such that lncRNAs can influence gene expression at multiple levels. Here we re ...[more]