Ontology highlight
ABSTRACT:
SUBMITTER: Taylor NA
PROVIDER: S-EPMC5669567 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Taylor Nicholas A NA Vick Sarah C SC Iglesia Michael D MD Brickey W June WJ Midkiff Bentley R BR McKinnon Karen P KP Reisdorf Shannon S Anders Carey K CK Carey Lisa A LA Parker Joel S JS Perou Charles M CM Vincent Benjamin G BG Serody Jonathan S JS
The Journal of clinical investigation 20170821 9
Claudin-low breast cancer is an aggressive subtype that confers poor prognosis and is found largely within the clinical triple-negative group of breast cancer patients. Here, we have shown that intrinsic and immune cell gene signatures distinguish the claudin-low subtype clinically as well as in mouse models of other breast cancer subtypes. Despite adaptive immune cell infiltration in claudin-low tumors, treatment with immune checkpoint inhibitory antibodies against cytotoxic T lymphocyte-associ ...[more]