Ontology highlight
ABSTRACT:
SUBMITTER: Lu P
PROVIDER: S-EPMC5669577 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Lu Paul P Ceto Steven S Wang Yaozhi Y Graham Lori L Wu Di D Kumamaru Hiromi H Staufenberg Eileen E Tuszynski Mark H MH
The Journal of clinical investigation 20170821 9
Neural stem cells (NSCs) differentiate into both neurons and glia, and strategies using human NSCs have the potential to restore function following spinal cord injury (SCI). However, the time period of maturation for human NSCs in adult injured CNS is not well defined, posing fundamental questions about the design and implementation of NSC-based therapies. This work assessed human H9 NSCs that were implanted into sites of SCI in immunodeficient rats over a period of 1.5 years. Notably, grafts sh ...[more]