Ontology highlight
ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC5669884 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wu Megan M Guan Jennifer J Li Chris C Gunter Simon S Nusrat Labeeba L Ng Sheena S Dhand Karan K Morshead Cindi C Kim Albert A Das Sunit S
Oncotarget 20170717 47
Glioblastoma recurrence after aggressive therapy typically occurs within six months, and patients inevitably succumb to their disease. Tumor recurrence is driven by a subpopulation of cancer stem cells in glioblastoma (glioblastoma stem-like cells, GSCs), which exhibit resistance to cytotoxic therapies, compared to their non-stem-cell counterparts. Here, we show that the Cox-2 and Wnt signaling pathways are aberrantly activated in GSCs and interact to maintain the cancer stem cell identity. Cox- ...[more]