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Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd3N@C80: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.

ABSTRACT: Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-Gd3N@C80, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-Gd3N@C80 more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-Gd3N@C80 also suppressed LPS-elicited mRNA expression of pro-inflammatory inducible nitric oxide synthase and tumor necrosis factor-alpha, and upregulated antioxidative enzyme axis Nrf2 and heme oxygenase-1, possibly via ERK but not AKT signaling pathways. Therefore, carboxyl-Gd3N@C80 held a great promise in becoming a novel theranostic nanoplatform for simultaneously deliver MRI contrast and therapeutic functions to inflammation-related diseases.

SUBMITTER: Li T 

PROVIDER: S-EPMC5670744 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd<sub>3</sub>N@C<sub>80</sub>: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.

Li Tinghui T   Xiao Li L   Yang Jiezuan J   Ding Mengmeng M   Zhou Zhiguo Z   LaConte Leslie L   Jin Li L   Dorn Harry C HC   Li Xudong X  

ACS applied materials & interfaces 20170519 21

Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-Gd<sub>3</sub>N@C<sub>80</sub>, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-Gd<sub>3</sub>N@C<sub>80</sub> more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-Gd  ...[more]

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