Ontology highlight
ABSTRACT:
SUBMITTER: Kostova KK
PROVIDER: S-EPMC5673106 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Kostova Kamena K KK Hickey Kelsey L KL Osuna Beatriz A BA Hussmann Jeffrey A JA Frost Adam A Weinberg David E DE Weissman Jonathan S JS
Science (New York, N.Y.) 20170701 6349
Ribosome stalling leads to recruitment of the ribosome quality control complex (RQC), which targets the partially synthesized polypeptide for proteasomal degradation through the action of the ubiquitin ligase Ltn1p. A second core RQC component, Rqc2p, modifies the nascent polypeptide by adding a carboxyl-terminal alanine and threonine (CAT) tail through a noncanonical elongation reaction. Here we examined the role of CAT-tailing in nascent-chain degradation in budding yeast. We found that Ltn1p ...[more]