Ontology highlight
ABSTRACT:
SUBMITTER: Osuna BA
PROVIDER: S-EPMC5562442 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Osuna Beatriz A BA Howard Conor J CJ Kc Subheksha S Frost Adam A Weinberg David E DE
eLife 20170718
Ribosomes can stall during translation due to defects in the mRNA template or translation machinery, leading to the production of incomplete proteins. The Ribosome-associated Quality control Complex (RQC) engages stalled ribosomes and targets nascent polypeptides for proteasomal degradation. However, how each RQC component contributes to this process remains unclear. Here we demonstrate that key RQC activities-Ltn1p-dependent ubiquitination and Rqc2p-mediated Carboxy-terminal Alanine and Threoni ...[more]