Small Ubiquitin-Like Modifier 4 (SUMO4) Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects.

ABSTRACT: Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter.A meta-analysis consisting of 6,823 subjects from 10 studies was conducted to elucidate relationship between the SUMO4 M55V gene polymorphism and T2DM. Depending on the heterogeneity of the data, either a fixed or random-effects model would be used to assess the combined odds ratio (ORs) and their corresponding 95% confidence interval (CI).SUMO4 gene M55V polymorphism was significantly associated with T2DM in the whole population under allelic (OR: 1.18, 95% CI: 1.10-1.28, P?=?1.63?×?10-5), recessive (OR: 1.59, 95% CI: 1.14-2.23, P?=?0.006), dominant (OR: 0.815, 95% CI: 0.737-0.901, P?=?6.89?×?10-5), homozygous (OR: 1.415, 95% CI: 1.170-1.710, P?=?0.0003), heterozygous (OR: 1.191, 95% CI: 1.072-1.323, P?=?0.001), and additive genetic models (OR: 1.184, 95% CI: 1.097-1.279, P?=?1.63?×?10-5). In our subgroup analysis, a significant association was found again in the Chinese population, but not in Japanese or Iranian population.SUMO4 gene M55V polymorphism may correlate with increased T2DM risk. Chinese carriers of the V allele of the SUMO4 gene M55V polymorphism may be predisposed to developing T2DM.

SUBMITTER: Li YY 

PROVIDER: S-EPMC5673665 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature