Trial watch: Immune checkpoint blockers for cancer therapy.
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ABSTRACT:
SUBMITTER: Vanpouille-Box C
PROVIDER: S-EPMC5674958 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Trial watch: Immune checkpoint blockers for cancer therapy.
Vanpouille-Box Claire C Lhuillier Claire C Bezu Lucillia L Aranda Fernando F Yamazaki Takahiro T Kepp Oliver O Fucikova Jitka J Spisek Radek R Demaria Sandra S Formenti Silvia C SC Zitvogel Laurence L Kroemer Guido G Galluzzi Lorenzo L
Oncoimmunology 20170831 11
Immune checkpoint blockers (ICBs) are literally revolutionizing the clinical management of an ever more diversified panel of oncological indications. Although considerable attention persists around the inhibition of cytotoxic T lymphocyte-associated protein 4 (CTLA4) and programmed cell death 1 (PDCD1, best known as PD-1) signaling, several other co-inhibitory T-cell receptors are being evaluated as potential targets for the development of novel ICBs. Moreover, substantial efforts are being devo ...[more]
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