Tribbles 3 regulates protein turnover in mouse skeletal muscle.
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ABSTRACT:
SUBMITTER: Choi RH
PROVIDER: S-EPMC5675010 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Tribbles 3 regulates protein turnover in mouse skeletal muscle.
Choi Ran Hee RH McConahay Abigail A Jeong Ha-Won HW McClellan Jamie L JL Hardee Justin P JP Carson James A JA Hirshman Michael F MF Goodyear Laurie J LJ Koh Ho-Jin HJ
Biochemical and biophysical research communications 20170927 3
Skeletal muscle atrophy is associated with a disruption in protein turnover involving increased protein degradation and suppressed protein synthesis. Although it has been well studied that the IGF-1/PI3K/Akt pathway plays an essential role in the regulation of the protein turnover, molecule(s) that triggers the change in protein turnover still remains to be elucidated. TRB3 has been shown to inhibit Akt through direct binding. In this study, we hypothesized that TRB3 in mouse skeletal muscle neg ...[more]
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