Ferrous iron efflux systems in bacteria.
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ABSTRACT:
SUBMITTER: Pi H
PROVIDER: S-EPMC5675029 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Ferrous iron efflux systems in bacteria.
Pi Hualiang H Helmann John D JD
Metallomics : integrated biometal science 20170701 7
Bacteria require iron for growth, with only a few reported exceptions. In many environments, iron is a limiting nutrient for growth and high affinity uptake systems play a central role in iron homeostasis. However, iron can also be detrimental to cells when it is present in excess, particularly under aerobic conditions where its participation in Fenton chemistry generates highly reactive hydroxyl radicals. Recent results have revealed a critical role for iron efflux transporters in protecting ba ...[more]
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