Ontology highlight
ABSTRACT:
SUBMITTER: Brown S
PROVIDER: S-EPMC5675114 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Brown Samara S Pineda Cristiana M CM Xin Tianchi T Boucher Jonathan J Suozzi Kathleen C KC Park Sangbum S Matte-Martone Catherine C Gonzalez David G DG Rytlewski Julie J Beronja Slobodan S Greco Valentina V
Nature 20170802 7667
Cells in healthy tissues acquire mutations with surprising frequency. Many of these mutations are associated with abnormal cellular behaviours such as differentiation defects and hyperproliferation, yet fail to produce macroscopically detectable phenotypes. It is currently unclear how the tissue remains phenotypically normal, despite the presence of these mutant cells. Here we use intravital imaging to track the fate of mouse skin epithelium burdened with varying numbers of activated Wnt/β-caten ...[more]