Ontology highlight
ABSTRACT:
SUBMITTER: Singh T
PROVIDER: S-EPMC6315686 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Singh Tania T Sarmiento Luis L Luan Cheng C Prasad Rashmi B RB Johansson Jenny J Cataldo Luis R LR Renström Erik E Soneji Shamit S Cilio Corrado C Artner Isabella I
Genes 20181218 12
Type 1 (T1D) and type 2 (T2D) diabetes are triggered by a combination of environmental and/or genetic factors. Maf transcription factors regulate pancreatic beta (β)-cell function, and have also been implicated in the regulation of immunomodulatory cytokines like interferon-β (IFNβ1). In this study, we assessed <i>MAFA</i> and <i>MAFB</i> co-expression with pro-inflammatory cytokine signaling genes in RNA-seq data from human pancreatic islets. Interestingly, <i>MAFA</i> expression was strongly n ...[more]