Unknown

Dataset Information

0

Immuno-virological response and associated factors amongst HIV-1 vertically infected adolescents in Yaounde-Cameroon.


ABSTRACT: Limited studies have reported the outcomes of lifelong antiretroviral therapy (ART) amongst adolescents living with HIV (ALWHIV) in resource-limited settings (RLS), thus classifying this population as underserved. We therefore aimed to ascertain the immunological and virological responses, and associated factors amongst Cameroonian ALWHIV.A cross-sectional and observational study was conducted from January through May 2016 at the National Social Insurance Fund Health Centre in Yaoundé-Cameroon. Immunological and virological responses were evaluated using CD4 cell count and viral load respectively, with viral suppression (VS) defined as <50 copies/ml. Adherence was evaluated using self-reported missing doses during the past 14 days. Data were analyzed using R v.3.3.0, with p<0.05 considered statistically significant.Of the 145 ALWHIV on ART enrolled in the study, 52% were female, median age [interquartile (IQR)] was 13 [11-16] years, median [IQR] time-on-ART was 7 [5-10] years, 48% were orphans, 92% were on first-line ART and 36% were adherent to ART. Following ART response, 79% (114/145) had CD4 ?500/mm3, 71.0% (103/145) were on VS of whom 52.4% (76/145) had a sustained VS. Duration of ART was associated with immune restoration (Odd Ratio 3.73 [1.26-12.21]) but not with virological response. Risks of poor adherence were greater in orphans of both parents (p = 0.078).In this urban setting of Cameroon, ALWHIV receiving ART show favorable immunological and virological response in a medium run. For long-term ART success, implementing a close monitoring of adherence and risks of viral rebound would be highly relevant, especially for orphans of both parents.

SUBMITTER: Fokam J 

PROVIDER: S-EPMC5675438 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immuno-virological response and associated factors amongst HIV-1 vertically infected adolescents in Yaoundé-Cameroon.

Fokam Joseph J   Billong Serge Clotaire SC   Jogue Franck F   Moyo Tetang Ndiang Suzie S   Nga Motaze Annie Carole AC   Paul Koki Ndombo KN   Njom Nlend Anne Esther AE  

PloS one 20171107 11


<h4>Introduction</h4>Limited studies have reported the outcomes of lifelong antiretroviral therapy (ART) amongst adolescents living with HIV (ALWHIV) in resource-limited settings (RLS), thus classifying this population as underserved. We therefore aimed to ascertain the immunological and virological responses, and associated factors amongst Cameroonian ALWHIV.<h4>Method</h4>A cross-sectional and observational study was conducted from January through May 2016 at the National Social Insurance Fund  ...[more]

Similar Datasets

| S-EPMC6422392 | biostudies-literature
| S-EPMC8118549 | biostudies-literature
| S-EPMC4906943 | biostudies-literature
| S-EPMC5517629 | biostudies-other
| S-EPMC4426308 | biostudies-literature
| S-EPMC4266669 | biostudies-literature
| S-EPMC11004643 | biostudies-literature
| S-EPMC5033457 | biostudies-literature
| S-EPMC4426320 | biostudies-literature
| S-EPMC3710986 | biostudies-literature