HLA Correlates of Long-Term Survival in Vertically Infected HIV-1-Positive Adolescents in Harare, Zimbabwe.
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ABSTRACT:
SUBMITTER: Shepherd BL
PROVIDER: S-EPMC4426308 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
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HLA Correlates of Long-Term Survival in Vertically Infected HIV-1-Positive Adolescents in Harare, Zimbabwe.
Shepherd Brittany L BL Ferrand Rashida R Munyati Shungu S Folkard Samuel S Boyd Kathryn K Bandason Tsitsi T Jallow Sabelle S Rowland-Jones Sarah L SL Yindom Louis-Marie LM
AIDS research and human retroviruses 20150209 5
African infants with vertically acquired HIV infection progress rapidly, with only 50% surviving beyond 2 years in the absence of treatment. Despite this high initial mortality, recent reports describe a substantial burden of older children living with untreated vertically acquired HIV infection in Southern Africa. The immunological and genetic factors associated with long-term survival following vertical infection are poorly understood. We performed medium-to-high resolution HLA typing on DNA s ...[more]
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