Ontology highlight
ABSTRACT:
SUBMITTER: Cheng XN
PROVIDER: S-EPMC5677176 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cheng Xiao-Ning XN Shao Ming M Li Ji-Tong JT Wang Yan-Fei YF Qi Jing J Xu Zhi-Gang ZG Shi De-Li DL
Nature communications 20171107 1
Gastrulation is a fundamental morphogenetic event that requires polarised cell behaviours for coordinated asymmetric cell movements. Wnt/PCP signalling plays a critical role in this process. Dishevelled is an important conserved scaffold protein that relays Wnt/PCP signals from membrane receptors to the modulation of cytoskeleton organisation. However, it remains unclear how its activity is regulated for the activation of downstream effectors. Here, we report that Lurap1 is a Dishevelled-interac ...[more]