Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.
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ABSTRACT:
SUBMITTER: Sundaresan V
PROVIDER: S-EPMC5677515 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.
Sundaresan Varsha V Lin Victor T VT Liang Faming F Kaye Frederic J FJ Kawabata-Iwakawa Reika R Shiraishi Kouya K Kohno Takashi T Yokota Jun J Zhou Lei L
Cancer genetics 20170607
Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers and demands effective targeted therapeutic strategies. In this meta-analysis study, we aim to identify significantly mutated genes and regulatory pathways to help us better understand the progression of SCLC and to identify potential biomarkers. Besides ranking genes based on their mutation frequencies, we sought to identify statistically significant mutations in SCLC with the MutSigCV software. Our analysis identif ...[more]
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