Ontology highlight
ABSTRACT:
SUBMITTER: Raiber EA
PROVIDER: S-EPMC5677956 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Raiber Eun-Ang EA Beraldi Dario D Martínez Cuesta Sergio S McInroy Gordon R GR Kingsbury Zoya Z Becq Jennifer J James Terena T Lopes Margarida M Allinson Kieren K Field Sarah S Humphray Sean S Santarius Thomas T Watts Colin C Bentley David D Balasubramanian Shankar S
NPJ genomic medicine 20170313
Aberrant genetic and epigenetic variations drive malignant transformation and are hallmarks of cancer. Using PCR-free sample preparation we achieved the first in-depth whole genome (hydroxyl)-methylcytosine, single-base-resolution maps from a glioblastoma tumour/margin sample of a patient. Our data provide new insights into how genetic and epigenetic variations are interrelated. In the tumour, global hypermethylation with a depletion of 5-hydroxymethylcytosine was observed. The majority of singl ...[more]