Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways.
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ABSTRACT:
SUBMITTER: Bomback AS
PROVIDER: S-EPMC5678788 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways.
Bomback Andrew S AS Markowitz Glen S GS Appel Gerald B GB
Kidney international reports 20160701 3
A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology. All 3 complement pathways-classical, lectin, and alternative-have been implicated in glomerular lesions both rare (e.g., dense deposit disease) and common (e.g., IgA nephropathy). Here we review the basic function of these pathways and highlight, with a disease-specific focus, how activation can lead to glomerular injury. We end by explorin ...[more]
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