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Organic CO Prodrugs: Structure-CO-Release Rate Relationship Studies.


ABSTRACT: Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure-release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described.

SUBMITTER: Pan Z 

PROVIDER: S-EPMC5679012 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Organic CO Prodrugs: Structure-CO-Release Rate Relationship Studies.

Pan Zhixiang Z   Chittavong Vayou V   Li Wei W   Zhang Jun J   Ji Kaili K   Zhu Mengyuan M   Ji Xingyue X   Wang Binghe B  

Chemistry (Weinheim an der Bergstrasse, Germany) 20170704 41


Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure-release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described. ...[more]

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