Ontology highlight
ABSTRACT:
SUBMITTER: Tothova Z
PROVIDER: S-EPMC5679060 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Tothova Zuzana Z Krill-Burger John M JM Popova Katerina D KD Landers Catherine C CC Sievers Quinlan L QL Yudovich David D Belizaire Roger R Aster Jon C JC Morgan Elizabeth A EA Tsherniak Aviad A Ebert Benjamin L BL
Cell stem cell 20171001 4
Hematologic malignancies are driven by combinations of genetic lesions that have been difficult to model in human cells. We used CRISPR/Cas9 genome engineering of primary adult and umbilical cord blood CD34<sup>+</sup> human hematopoietic stem and progenitor cells (HSPCs), the cells of origin for myeloid pre-malignant and malignant diseases, followed by transplantation into immunodeficient mice to generate genetic models of clonal hematopoiesis and neoplasia. Human hematopoietic cells bearing mu ...[more]