FGF19, FGF21, and an FGFR1/?-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.
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ABSTRACT:
SUBMITTER: Lan T
PROVIDER: S-EPMC5679468 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.
Lan Tian T Morgan Donald A DA Rahmouni Kamal K Sonoda Junichiro J Fu Xiaorong X Burgess Shawn C SC Holland William L WL Kliewer Steven A SA Mangelsdorf David J DJ
Cell metabolism 20171005 5
Despite the different physiologic functions of FGF19 and FGF21 as hormonal regulators of fed and fasted metabolism, their pharmacologic administration causes similar increases in energy expenditure, weight loss, and enhanced insulin sensitivity in obese animals. Here, in genetic loss-of-function studies of the shared co-receptor β-Klotho, we show that these pharmacologic effects are mediated through a common, tissue-specific pathway. Surprisingly, FGF19 and FGF21 actions in liver and adipose tis ...[more]
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