Ontology highlight
ABSTRACT:
SUBMITTER: Ku B
PROVIDER: S-EPMC5679558 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Ku Bonsu B Hong Won W Keum Chae Won CW Kim Myeongbin M Ryu Hyunyeol H Jeon Donghwan D Shin Ho-Chul HC Kim Jae Hoon JH Kim Seung Jun SJ Ryu Seong Eon SE
PloS one 20171109 11
Dual-specificity phosphatases (DUSPs) constitute a subfamily of protein tyrosine phosphatases, and are intimately involved in the regulation of diverse parameters of cellular signaling and essential biological processes. DUSP28 is one of the DUSP subfamily members that is known to be implicated in the progression of hepatocellular and pancreatic cancers, and its biological functions and enzymatic characteristics are mostly unknown. Herein, we present the crystal structure of human DUSP28 determi ...[more]