Ontology highlight
ABSTRACT:
SUBMITTER: Zhu LQ
PROVIDER: S-EPMC6632239 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Zhu Ling-Qiang LQ Zheng Hong-Yun HY Peng Cai-Xia CX Liu Dan D Li Hong-Lian HL Wang Qun Q Wang Jian-Zhi JZ
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100301 10
Protein phosphatase 2A (PP2A) is indispensable in development, and deficits of PP2A and deterioration of neuronal axons have been observed in several neurodegenerative disorders, but the direct link between PP2A and the neuronal axon development is still missing. Here, we show that PP2A is essential for axon development in transfected rat brain and the dissociated hippocampal neurons. Upregulation of PP2A catalytic subunit (PP2Ac) not only promotes formation and elongation of the functional axon ...[more]