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Quantitative single breath-hold renal arterial spin labeling imaging at 7T.

ABSTRACT: PURPOSE:To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T. METHODS:A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion study was performed using the single subtraction approach. To address issues of B1+ inhomogeneity/efficiency and excessive short-term specific absorption rates, various strategies were used, such as dynamic radiofrequency shimming and optimization. RESULTS:A conservative temporal bolus width of 600 ms determined from the multi-delay study was applied for single-subtraction imaging to measure the renal blood flow in the cortex and medulla: 303?±?31.8 and 91.3?±?15.2 (mL/100?g/min), respectively. The estimated spatial and temporal signal-to-noise ratios of renal perfusion measurements were 3.8?±?0.7 and 2.4?±?0.6 for the cortex, and 2.2?±?0.6 and 1.4?±?0.2 for the medulla. CONCLUSION:With proper management of field strength specific challenges, quantitative renal ASL imaging can be achieved at 7T within a single breath-hold. Magn Reson Med 79:815-825, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Li X

PROVIDER: S-EPMC5680158 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Quantitative single breath-hold renal arterial spin labeling imaging at 7T.

Li Xiufeng X Auerbach Edward J EJ Van de Moortele Pierre-Francois PF Ugurbil Kamil K Metzger Gregory J GJ

Magnetic resonance in medicine 20170509 2

<h4>Purpose</h4>To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T.<h4>Methods</h4>A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion st ...[more]

PMID: 28488274

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Project description:To assess the value of arterial spin-labeling (ASL) perfusion magnetic resonance (MR) imaging in the characterization of solid renal masses by using histopathologic findings as the standard of reference.This prospective study was compliant with HIPAA and approved by the institutional review board. Informed consent was obtained from all patients before imaging. Forty-two consecutive patients suspected of having renal masses underwent ASL MR imaging before their routine 1.5-T clinical MR examination. Mean and peak tumor perfusion levels were obtained by one radiologist, who was blinded to the final histologic diagnosis, by using region of interest analysis. Perfusion values were correlated with histopathologic findings by using analysis of variance. A linear correlation model was used to evaluate the relationship between tumor size and perfusion in clear cell renal cell carcinoma (RCC). P < .05 was considered indicative of a statistically significant difference.Histopathologic findings were available in 34 patients (28 men, six women; mean age ± standard deviation, 60.4 years ± 11.7). The mean perfusion of papillary RCC (27.0 mL/min/100 g ± 15.1) was lower than that of clear cell RCC (171.6 mL/min/100 g ± 61.2, P = .001), chromophobe RCC (152.9 mL/min/100 g ± 80.7, P = .04), unclassified RCC (208.0 mL/min/100 g ± 41.1, P = .001), and oncocytoma (373.9 mL/min/100 g ± 99.2, P < .001). The mean and peak perfusion levels of oncocytoma (373.9 mL/min/100 g ± 99.2 and 512.3 mL/min/100 g ± 146.0, respectively) were higher than those of papillary RCC (27.0 mL/min/100 g ± 15.1 and 78.2 mL/min/100 g ± 39.7, P < .001 for both), chromophobe RCC (152.9 mL/min/100 g ± 80.7 and 260.9 mL/min/100 g ± 61.9; P < .001 and P = .02, respectively), and unclassified RCC (208.0 mL/min/100 g ± 41.1 and 273.3 mL/min/100 g ± 83.4; P = .01 and P = .03, respectively). The mean tumor perfusion of oncocytoma was higher than that of clear cell RCC (P < .001).ASL MR imaging enables distinction among different histopathologic diagnoses in renal masses on the basis of their perfusion level. Oncocytomas demonstrate higher perfusion levels than RCCs, and papillary RCCs exhibit lower perfusion levels than other RCC subtypes.

Dataset Information

Quantitative single breath-hold renal arterial spin labeling imaging at 7T.

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Quantitative single breath-hold renal arterial spin labeling imaging at 7T.

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