Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC5680226 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Chen Bojun B Liu Ping P Hujber Edward J EJ Li Yan Y Jorgensen Erik M EM Wang Zhao-Wen ZW
Nature communications 20171109 1
Pituitary tumors are frequently associated with mutations in the AIP gene and are sometimes associated with hypersecretion of growth hormone. It is unclear whether other factors besides an enlarged pituitary contribute to the hypersecretion. In a genetic screen for suppressors of reduced neurotransmitter release, we identified a mutation in Caenorhabditis elegans AIPR-1 (AIP-related-1), which causes profound increases in evoked and spontaneous neurotransmitter release, a high frequency of sponta ...[more]