Ontology highlight
ABSTRACT:
SUBMITTER: Mann AP
PROVIDER: S-EPMC5680235 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Mann Aman P AP Scodeller Pablo P Hussain Sazid S Braun Gary B GB Mölder Tarmo T Toome Kadri K Ambasudhan Rajesh R Teesalu Tambet T Lipton Stuart A SA Ruoslahti Erkki E
Nature communications 20171110 1
Cerebrovascular changes occur in Alzheimer's disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus of hAPP-J20 mice at different ages. Intravenously injected DAG peptide homes to neurovascular unit endothelial cells and to reactive astrocytes in mouse models of AD. We identified connective tissue ...[more]