Ontology highlight
ABSTRACT:
SUBMITTER: Donkers JM
PROVIDER: S-EPMC5681660 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Donkers Joanne M JM Zehnder Benno B van Westen Gerard J P GJP Kwakkenbos Mark J MJ IJzerman Adriaan P AP Oude Elferink Ronald P J RPJ Beuers Ulrich U Urban Stephan S van de Graaf Stan F J SFJ
Scientific reports 20171110 1
The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) is the main hepatic transporter of conjugated bile acids, and the entry receptor for hepatitis B virus (HBV) and hepatitis delta virus (HDV). Myrcludex B, a synthetic peptide mimicking the NTCP-binding domain of HBV, effectively blocks HBV and HDV infection. In addition, Myrcludex B inhibits NTCP-mediated bile acid uptake, suggesting that also other NTCP inhibitors could potentially be a novel treatment of HBV/HDV infection. Thi ...[more]