Ontology highlight
ABSTRACT:
SUBMITTER: Hoshino Y
PROVIDER: S-EPMC5682356 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Hoshino Yoshikazu Y Mizuno Seiya S Kato Kanako K Mizuno-Iijima Saori S Tanimoto Yoko Y Ishida Miyuki M Kajiwara Noriko N Sakasai Tomoki T Miwa Yoshihiro Y Takahashi Satoru S Yagami Ken-Ichi KI Sugiyama Fumihiro F
Experimental animals 20170718 4
The in vivo imaging of mice makes it possible to analyze disease progress non-invasively through reporter gene expression. As the removal of hair improves the accuracy of in vivo imaging, gene-modified mice with a reporter gene are often crossed with Hos:HR-1 mutant mice homozygous for the spontaneous Hr<sup>hr</sup> mutation that exhibit a hair loss phenotype. However, it is time consuming to produce mice carrying both the reporter gene and mutant Hr<sup>hr</sup> gene by mating. In addition, th ...[more]