Ontology highlight
ABSTRACT:
SUBMITTER: Daum JM
PROVIDER: S-EPMC5685475 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Daum Janine M JM Keles Özkan Ö Holwerda Sjoerd Jb SJ Kohler Hubertus H Rijli Filippo M FM Stadler Michael M Roska Botond B
eLife 20171106
High-resolution daylight vision is mediated by cone photoreceptors. The molecular program responsible for the formation of their light sensor, the outer segment, is not well understood. We correlated daily changes in ultrastructure and gene expression in postmitotic mouse cones, between birth and eye opening, using serial block-face electron microscopy (EM) and RNA sequencing. Outer segments appeared rapidly at postnatal day six and their appearance coincided with a switch in gene expression. Th ...[more]