Targeting microbial biofilms: current and prospective therapeutic strategies.
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ABSTRACT:
SUBMITTER: Koo H
PROVIDER: S-EPMC5685531 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Targeting microbial biofilms: current and prospective therapeutic strategies.
Koo Hyun H Allan Raymond N RN Howlin Robert P RP Stoodley Paul P Hall-Stoodley Luanne L
Nature reviews. Microbiology 20170925 12
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections. The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobials and indicates the need for multi-targeted or combinatorial therapies. In this Review, we focus on current therapeutic strategies and those under development that target vital structural and functional traits of microbial biofilms and drug tolerance mecha ...[more]
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