Therapeutic strategies targeting connexins.
Ontology highlight
ABSTRACT:
SUBMITTER: Laird DW
PROVIDER: S-EPMC6461534 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Therapeutic strategies targeting connexins.
Laird Dale W DW Lampe Paul D PD
Nature reviews. Drug discovery 20181012 12
The connexin family of channel-forming proteins is present in every tissue type in the human anatomy. Connexins are best known for forming clustered intercellular channels, structurally known as gap junctions, where they serve to exchange members of the metabolome between adjacent cells. In their single-membrane hemichannel form, connexins can act as conduits for the passage of small molecules in autocrine and paracrine signalling. Here, we review the roles of connexins in health and disease, fo ...[more]
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