Ontology highlight
ABSTRACT:
SUBMITTER: Xia AL
PROVIDER: S-EPMC5685771 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Xia An-Liang AL Wang Xiao-Chen XC Lu Yi-Jun YJ Lu Xiao-Jie XJ Sun Beicheng B
Oncotarget 20170718 52
Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have ...[more]