Ontology highlight
ABSTRACT:
SUBMITTER: Newick K
PROVIDER: S-EPMC4849432 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Newick Kheng K Moon Edmund E Albelda Steven M SM
Molecular therapy oncolytics 20160413
Chimeric antigen receptor (CAR) T cells are engineered constructs composed of synthetic receptors that direct T cells to surface antigens for subsequent elimination. Many CAR constructs are also manufactured with elements that augment T-cell persistence and activity. To date, CAR T cells have demonstrated tremendous success in eradicating hematological malignancies (e.g., CD19 CARs in leukemias). This success is not yet extrapolated to solid tumors, and the reasons for this are being actively in ...[more]