Ontology highlight
ABSTRACT:
SUBMITTER: Tang Z
PROVIDER: S-EPMC5686350 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Tang Zhenyuan Z Takahashi Yoshinori Y Chen Chong C Liu Ying Y He Haiyan H Tsotakos Nikolaos N Serfass Jacob M JM Gebru Melat T MT Chen Han H Young Megan M MM Wang Hong-Gang HG
Cell death and differentiation 20170811 12
Autophagosomal membranes are emerging as platforms for various cell survival and death signaling networks beyond autophagy. While autophagy-dependent cell death has been reported in response to a variety of stimuli, the underlying molecular mechanisms remain far from clear. Here, we demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intr ...[more]