Ontology highlight
ABSTRACT:
SUBMITTER: Mochizuki AL
PROVIDER: S-EPMC5686578 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Mochizuki Ayako L AL Katanaya Ami A Hayashi Eri E Hosokawa Mihoko M Moribe Emiko E Motegi Akira A Ishiai Masamichi M Takata Minoru M Kondoh Gen G Watanabe Hitomi H Nakatsuji Norio N Chuma Shinichiro S
Molecular and cellular biology 20171113 23
DNA replication is frequently perturbed by intrinsic, as well as extrinsic, genotoxic stress. At damaged forks, DNA replication and repair activities require proper coordination to maintain genome integrity. We show here that PARI antirecombinase plays an essential role in modulating the initial response to replication stress in mice. PARI is functionally dormant at replisomes during normal replication, but upon replication stress, it enhances nascent-strand shortening that is regulated by RAD51 ...[more]