Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee C
PROVIDER: S-EPMC6650494 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mukherjee Chirantani C Tripathi Vivek V Manolika Eleni Maria EM Heijink Anne Margriet AM Ricci Giulia G Merzouk Sarra S de Boer H Rudolf HR Demmers Jeroen J van Vugt Marcel A T M MATM Ray Chaudhuri Arnab A
Nature communications 20190723 1
Homologous recombination (HR) and Fanconi Anemia (FA) pathway proteins in addition to their DNA repair functions, limit nuclease-mediated processing of stalled replication forks. However, the mechanism by which replication fork degradation results in genome instability is poorly understood. Here, we identify RIF1, a non-homologous end joining (NHEJ) factor, to be enriched at stalled replication forks. Rif1 knockout cells are proficient for recombination, but displayed degradation of reversed for ...[more]