Diosgenyl 2-amino-2-deoxy-?-D-galactopyranoside: synthesis, derivatives and antimicrobial activity.
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ABSTRACT:
SUBMITTER: Myszka H
PROVIDER: S-EPMC5687012 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity.
Myszka Henryk H Sokołowska Patrycja P Cieślińska Agnieszka A Nowacki Andrzej A Jaśkiewicz Maciej M Kamysz Wojciech W Liberek Beata B
Beilstein journal of organic chemistry 20171101
The synthesis of diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as <i>N</i>-acyl, 2-ureido, <i>N</i>-alkyl, and <i>N</i>,<i>N</i>-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compounds are active against Gram-positive bacteria and <i>Candida</i> type fungi. ...[more]
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