Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz SL
PROVIDER: S-EPMC5687039 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Schwartz Samantha L SL Cleyrat Cédric C Olah Mark J MJ Relich Peter K PK Phillips Genevieve K GK Hlavacek William S WS Lidke Keith A KA Wilson Bridget S BS Lidke Diane S DS
Molecular biology of the cell 20170830 23
Cross-linking of immunoglobulin E-bound FcεRI triggers multiple cellular responses, including degranulation and cytokine production. Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcεRI immunoreceptor tyrosine-based activation motifs. Using single-molecule imaging in live cells, we directly visualized and quantified the binding of individual mNeonGreen-tagged Syk molecules as they associated with the plasma membrane after F ...[more]