XCell: digitally portraying the tissue cellular heterogeneity landscape.
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ABSTRACT:
SUBMITTER: Aran D
PROVIDER: S-EPMC5688663 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
xCell: digitally portraying the tissue cellular heterogeneity landscape.
Aran Dvir D Hu Zicheng Z Butte Atul J AJ
Genome biology 20171115 1
Tissues are complex milieus consisting of numerous cell types. Several recent methods have attempted to enumerate cell subsets from transcriptomes. However, the available methods have used limited sources for training and give only a partial portrayal of the full cellular landscape. Here we present xCell, a novel gene signature-based method, and use it to infer 64 immune and stromal cell types. We harmonized 1822 pure human cell type transcriptomes from various sources and employed a curve fitti ...[more]
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