Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5690281 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zhang Yaqing Y Yan Wei W Mathew Esha E Kane Kevin T KT Brannon Arthur A Adoumie Maeva M Vinta Alekya A Crawford Howard C HC Pasca di Magliano Marina M
eLife 20171005
Dedifferentiation of acini to duct-like cells occurs during the physiologic damage response in the pancreas, but this process can be co-opted by oncogenic Kras to drive carcinogenesis. Myeloid cells infiltrate the pancreas during the onset of pancreatic cancer, and promote carcinogenesis. Here, we show that the function of infiltrating myeloid cells is regulated by oncogenic Kras expressed in epithelial cells. In the presence of oncogenic Kras, myeloid cells promote acinar dedifferentiation and ...[more]