Ontology highlight
ABSTRACT:
SUBMITTER: Siira SJ
PROVIDER: S-EPMC5691074 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Siira Stefan J SJ Spåhr Henrik H Shearwood Anne-Marie J AJ Ruzzenente Benedetta B Larsson Nils-Göran NG Rackham Oliver O Filipovska Aleksandra A
Nature communications 20171116 1
The expression of the compact mammalian mitochondrial genome requires transcription, RNA processing, translation and RNA decay, much like the more complex chromosomal systems, and here we use it as a model system to understand the fundamental aspects of gene expression. Here we combine RNase footprinting with PAR-CLIP at unprecedented depth to reveal the importance of RNA-protein interactions in dictating RNA folding within the mitochondrial transcriptome. We show that LRPPRC, in complex with it ...[more]