GENE-55. CONSTITUTIONAL MUTATIONS IN TERT AND MENINGIOMA RISK

ABSTRACT: Abstract INTRODUCTION Telomere-associated constitutional and somatic variants have been associated with etiology and outcome in glioma but have not yet been studied extensively in meningioma. METHODS Constitutional DNA from 275 meningioma patients (Grade I and II) and 1142 controls was evaluated for 1258 preselected telomere associated SNPs using a log-additive model. Odds ratios (OR) and 95% Confidence Intervals were calculated with a Bonferroni-correction applied for multiple testing (p=3.98*10-5). RESULTS SNPs at 4 different loci were significantly associated with increased meningioma risk: 5q23 (rs739719, p=5.75*10-7, OR:2.08), 10q23 (rs9420907; p=3.23*10-6; OR:1.73, rs911547; p=4.31*10-6, OR:1.70), and 12q12 (rs7956602; p=1.85*10-5, OR:1.575, rs1641528; p=2.15*10-6, OR:1.80), and 17p13 (rs4602096; p=1.91*10-5, OR:1.60). SNPS at loci 10q23 (rs2067832; p=2.28*10-5, OR:0.66, rs9325507; p=2.28*10-5; OR:0.66, rs2273698; p=2.28*10-5, OR:0.66, rs11191865; p=3.66*10-5, OR:0.67) were associated with lower incidence of meningioma. CONCLUSIONS These results are the first to identify an association between meningioma risk and TERT and confirm the previously reported association of chr10 with meningioma risk.

SUBMITTER: Muskens I 

PROVIDER: S-EPMC5692414 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature