Ontology highlight
ABSTRACT:
SUBMITTER: Kang JK
PROVIDER: S-EPMC5692539 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Kang Jin Ku JK Kim Ok-Hee OH Hur June J Yu So Hee SH Lamichhane Santosh S Lee Jin Wook JW Ojha Uttam U Hong Jeong Hee JH Lee Cheol Soon CS Cha Ji-Young JY Lee Young Jae YJ Im Seung-Soon SS Park Young Joo YJ Choi Cheol Soo CS Lee Dae Ho DH Lee In-Kyu IK Oh Byung-Chul BC
Proceedings of the National Academy of Sciences of the United States of America 20171025 45
Insulin resistance, a key etiological factor in metabolic syndrome, is closely linked to ectopic lipid accumulation and increased intracellular Ca<sup>2+</sup> concentrations in muscle and liver. However, the mechanism by which dysregulated intracellular Ca<sup>2+</sup> homeostasis causes insulin resistance remains elusive. Here, we show that increased intracellular Ca<sup>2+</sup> acts as a negative regulator of insulin signaling. Chronic intracellular Ca<sup>2+</sup> overload in hepatocytes du ...[more]