Ontology highlight
ABSTRACT:
SUBMITTER: Guo G
PROVIDER: S-EPMC6560632 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Guo Gongrui G Xu Min M Chang Yanqi Y Luyten Tomas T Seitaj Bruno B Liu Wu W Zhu Ping P Bultynck Geert G Shi Lei L Quick Matthias M Liu Qun Q
Structure (London, England : 1993) 20190328 6
The anti-apoptotic transmembrane Bax inhibitor motif (TMBIM) containing protein family regulates Ca<sup>2+</sup> homeostasis, cell death, and the progression of diseases including cancers. The recent crystal structures of the TMBIM homolog BsYetJ reveal a conserved Asp171-Asp195 dyad that is proposed in regulating a pH-dependent Ca<sup>2+</sup> translocation. Here we show that BsYetJ mediates Ca<sup>2+</sup> fluxes in permeabilized mammalian cells, and its interaction with Ca<sup>2+</sup> is sen ...[more]