Ontology highlight
ABSTRACT:
SUBMITTER: Wong King Yuen SM
PROVIDER: S-EPMC5692558 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Wong King Yuen Siobhan M SM Campiglio Marta M Tung Ching-Chieh CC Flucher Bernhard E BE Van Petegem Filip F
Proceedings of the National Academy of Sciences of the United States of America 20171023 45
Excitation-contraction (EC) coupling in skeletal muscle requires functional and mechanical coupling between L-type voltage-gated calcium channels (Ca<sub>V</sub>1.1) and the ryanodine receptor (RyR1). Recently, STAC3 was identified as an essential protein for EC coupling and is part of a group of three proteins that can bind and modulate L-type voltage-gated calcium channels. Here, we report crystal structures of tandem-SH3 domains of different STAC isoforms up to 1.2-Å resolution. These form a ...[more]