Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC5692577 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Li Xiaobo X Yang Hongbao H Sun Hao H Lu Runze R Zhang Chengcheng C Gao Na N Meng Qingtao Q Wu Shenshen S Wang Susanna S Aschner Michael M Wu Jiong J Tang Boping B Gu Aihua A Kay Steve A SA Chen Rui R
Proceedings of the National Academy of Sciences of the United States of America 20171025 45
Chronic obstructive pulmonary disease (COPD) has been linked to particulate matter (PM) exposure. Using transcriptomic analysis, we demonstrate that diesel exhaust particles, one of the major sources of particulate emission, down-regulated genes located in mitochondrial complexes I and V and induced experimental COPD in a mouse model. 1-Nitropyrene was identified as a major toxic component of PM-induced COPD. In the panel study, COPD patients were found to be more susceptible to PM than individu ...[more]